Creepy High-Pitched Voice

Films-Animated

 * The Nightmare Before Christmas:
 * Jack Skellington

Western Animation

 * Aaahh!!! Real Monsters: Downplayed with the Gromble. He has a high-pitched voice and is a Large Ham, and acts like a Sadist Teacher sometimes, but deep down, he seems to really care for his students.
 * HIM from The Powerpuff Girls has a very effeminate-sounding voice, fitting for his status as a Sissy Villain. Although the reverb effect in his voice is one of the things that actually make him legitimately scary.