The Powerpuff Girls

One of Cartoon Network's most popular original series, The Powerpuff Girls revolves around a Power Trio of Little Miss Badasses who fight crime in the fictional city of Townsville. These Artificial Human girls, who have no fingers, toes, flat feet, ears, or noses, were created when Professor Utonium accidentally added Chemical X to his mixture of sugar, spice, and everything nice.

The series' heroes are Blossom, "commander and the leader," Bubbles, "the joy and the laughter," whose personality is very similar to that of her namesake from Jabberjaw (but not quite a Dumb Blonde), and Buttercup, "the toughest fighter," and a tomboy with a bad attitude. Their simian Arch-Enemy Mojo Jojo wears a helmet to cover his enlarged brain and speaks in a manner reminiscent of bad anime dubbing.

The concept began life as creator Craig McCracken's CalArts thesis film, titled "The Whoopass Girls" (they were created with "sugar, spice, everything nice," and a can of Whoopass) and was then adapted, with a slightly safer-for-work name, into two pilots for the What A Cartoon! Show. Cartoon Network decided to go with one of the other shorts, created by McCracken's friend and former 2 Stupid Dogs colleague Genndy Tartakovsky, as their first series, giving Craig a little more experience before his show finally went to series in 1998. Both artists worked on one another's respective shows.